Target：EPS8

Gene Name：EPS8

Protein Name：Epidermal growth factor receptor kinase substrate 8

Human Gene Id：2059

Human Swiss Prot No：Q12929

Mouse Swiss Prot No：Q08509

Immunogen：Synthesized peptide derived from human protein . at AA range: 130-210

Specificity：EPS8 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：90kD

Background： This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],

Function：domain:The SH3 domain mediates interaction with SHB.,function:Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.,PTM:Phosphorylated by several receptor tyrosine kinases.,similarity:Belongs to the EPS8 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer (By similarity). Interacts with BAIAP2. Interacts with SHB.,tissue specificity:Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.,

Subcellular Location：Cytoplasm, cell cortex . Cell projection, ruffle membrane . Cell projection, growth cone . Cell projection, stereocilium . Cell junction, synapse, synaptosome . Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells. .

Expression：Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.