Target：GDF-8

Fields：Cytokine-cytokine receptor interaction

Gene Name：MSTN

Protein Name：Growth/differentiation factor 8

Human Gene Id：2660

Human Swiss Prot No：O14793

Mouse Gene Id：17700

Mouse Swiss Prot No：O08689

Immunogen：The antiserum was produced against synthesized peptide derived from human GDF-8. AA range:38-87

Specificity：GDF-8 Polyclonal Antibody detects endogenous levels of GDF-8 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MSTN;GDF8;Growth/differentiation factor 8;GDF-8;Myostatin

Molecular Weight(Da)：43kD

Background：myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],

Function：function:Acts specifically as a negative regulator of skeletal muscle growth.,online information:Myostatin entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.,

Subcellular Location：Secreted .

Expression： Colon,Muscle,Pericardium,Skeletal muscle,