Target：ARA70

Fields：Ferroptosis;Pathways in cancer;Thyroid cancer

Gene Name：NCOA4

Protein Name：Nuclear receptor coactivator 4

Human Gene Id：8031

Human Swiss Prot No：Q13772

Immunogen：Synthesized peptide derived from ARA70 . at AA range: 320-400

Specificity：ARA70 Polyclonal Antibody detects endogenous levels of ARA70 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000. IP 1:50-200Not yet tested in other applications.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NCOA4;ARA70;ELE1;RFG;Nuclear receptor coactivator 4;NCoA-4;Androgen receptor coactivator 70 kDa protein;70 kDa AR-activator;70 kDa androgen receptor coactivator;Androgen receptor-associated protein of 70 kDa;Ret-activating protein

Observed Band(KD)：70kD

Background： This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009],

Function：alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving NCOA4 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas.,function:Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.,polymorphism:Polymorphisms are specific to isoform alpha. Not found in isoform beta. Could be encoded by two different genes.,subunit:Interacts with the androgen receptor and the retinoid X receptor (RXR) in a ligand-dependent manner.,tissue specificity:Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform beta is only expressed in testis

Subcellular Location：nucleus,autolysosome,

Expression：Widely expressed. Also detected in adipose tissues and in different cell lines. Isoform Beta is only expressed in testis.