Target：DSCAM

Gene Name：DSCAM

Protein Name：Down syndrome cell adhesion molecule (CHD2)

Human Gene Id：1826

Human Swiss Prot No：O60469

Mouse Swiss Prot No：Q9ERC8

Rat Swiss Prot No：Q8VHZ8

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：DSCAM Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：221kD

Background： This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],

Function：function:Cell adhesion molecule that can mediate cation-independent homophilic binding activity. Could be involved in nervous system development.,similarity:Contains 10 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 6 fibronectin type-III domains.,tissue specificity:Primarily expressed in brain.,

Subcellular Location：[Isoform Short]: Secreted .; [Isoform Long]: Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell projection, growth cone . Cell junction, synapse . Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. .

Expression：Primarily expressed in brain.