Target：DHS
Gene Name：DHPS
Protein Name：Deoxyhypusine synthase
Human Gene Id：1725
Human Swiss Prot No：P49366
Mouse Swiss Prot No：Q3TXU5
Immunogen：The antiserum was produced against synthesized peptide derived from human DHPS. AA range:51-100
Specificity：DHS Polyclonal Antibody detects endogenous levels of DHS protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：DHPS;DS;Deoxyhypusine synthase;DHS
Observed Band(KD)：45kD
Background： This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011],
Function：catalytic activity:[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.,cofactor:NAD.,function:Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.,pathway:Protein modification; eIF5A hypusination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the deoxyhypusine synthase family.,subunit:Homotetramer formed by a dimer of dimers.,
Subcellular Location：cytoplasm,cytosol,
Expression： Blood,Brain,Cervix carcinoma,Lung,
