Target:DHODH
Fields:Pyrimidine metabolism;Metabolic pathways;Biosynthesis of cofactors
Gene Name:DHODH
Protein Name:Dihydroorotate dehydrogenase
Human Gene Id:1723
Human Swiss Prot No:Q02127
Mouse Swiss Prot No:O35435
Immunogen:The antiserum was produced against synthesized peptide derived from human DHODH. AA range:211-260
Specificity:DHODH Polyclonal Antibody detects endogenous levels of DHODH protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:DHODH;Dihydroorotate dehydrogenase;quinone); mitochondrial;DHOdehase;Dihydroorotate oxidase
Observed Band(KD):48kD
Background: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008],
Function:catalytic activity:(S)-dihydroorotate + O(2) = orotate + H(2)O(2).,cofactor:Binds 1 FAD per subunit.,pathway:Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6.,similarity:Belongs to the dihydroorotate dehydrogenase family.,
Subcellular Location:Mitochondrion inner membrane ; Single-pass membrane protein .
Expression: Skin,Testis,