Target：DGK-κ

Fields：Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;Choline metabolism in cancer

Gene Name：DGKK

Protein Name：Diacylglycerol kinase kappa

Human Gene Id：139189

Human Swiss Prot No：Q5KSL6

Immunogen：The antiserum was produced against synthesized peptide derived from human DGKK. AA range:1221-1270

Specificity：DGK-κ Polyclonal Antibody detects endogenous levels of DGK-κ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DGKK;Diacylglycerol kinase kappa;DAG kinase kappa;142 kDa diacylglycerol kinase;Diglyceride kinase kappa;DGK-kappa

Observed Band(KD)：142kD

Background： The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011],

Function：catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,enzyme regulation:Inhibited in response to H(2)O(2).,function:Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).,PTM:Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).,similarity:Belongs to the eukaryotic diacylglycerol kinase family.,similarity:Contains 1 DAGKc domain.,similarity:Contains 1 PH domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Does not form homooligomers.,tissue specificity:Expressed in testis, and to a lesser extent in placenta.,

Subcellular Location：Cell membrane ; Peripheral membrane protein .

Expression：Expressed in testis, and to a lesser extent in placenta.