Target：DGAT2L3

Gene Name：AWAT1

Protein Name：Acyl-CoA wax alcohol acyltransferase 1

Human Gene Id：158833

Human Swiss Prot No：Q58HT5

Mouse Swiss Prot No：A2ADU9

Immunogen：The antiserum was produced against synthesized peptide derived from human AWAT1. AA range:261-310

Specificity：DGAT2L3 Polyclonal Antibody detects endogenous levels of DGAT2L3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AWAT1;DGA2;DGAT2L3;Acyl-CoA wax alcohol acyltransferase 1;Diacylglycerol O-acyltransferase 2-like protein 3;Diacylglycerol acyltransferase 2;Long-chain-alcohol O-fatty-acyltransferase 1

Observed Band(KD)：39kD

Background： The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009],

Function：catalytic activity:Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester.,function:Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20).,similarity:Belongs to the diacylglycerol acyltransferase family.,tissue specificity:Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis.,

Subcellular Location：Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Expression：Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis.