Target：Dectin-2

Fields：C-type lectin receptor signaling pathway

Gene Name：CLEC6A

Protein Name：C-type lectin domain family 6 member A

Human Gene Id：93978

Human Swiss Prot No：Q6EIG7

Mouse Swiss Prot No：Q9JKF4

Immunogen：Synthesized peptide derived from the Internal region of human Dectin-2.

Specificity：Dectin-2 Polyclonal Antibody detects endogenous levels of Dectin-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CLEC6A;CLECSF10;DECTIN2;C-type lectin domain family 6 member A;C-type lectin superfamily member 10;Dendritic cell-associated C-type lectin 2;DC-associated C-type lectin 2;Dectin-2

Observed Band(KD)：23kD

Background： The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

Function：function:May be involved in regulating immune reactivity.,similarity:Contains 1 C-type lectin domain.,tissue specificity:Expressed in dendritic cells.,

Subcellular Location：Cell membrane ; Single-pass type II membrane protein .

Expression：Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.