Target：GBP4

Fields：NOD-like receptor signaling pathway

Gene Name：GBP4

Protein Name：Guanylate-binding protein 4

Human Gene Id：115361

Human Swiss Prot No：Q96PP9

Mouse Swiss Prot No：Q61107

Immunogen：The antiserum was produced against synthesized peptide derived from human GBP4. AA range:551-600

Specificity：GBP4 Polyclonal Antibody detects endogenous levels of GBP4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GBP4;Guanylate-binding protein 4;GTP-binding protein 4;GBP-4;Guanine nucleotide-binding protein 4

Observed Band(KD)：73kD

Background： Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008],

Function：function:Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation.,similarity:Belongs to the GBP family.,

Subcellular Location：Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Golgi apparatus membrane . Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus. .

Expression： Brain,Epithelium,Placenta,Spinal cord,Spleen,Testis,