Target：COL19A1

Fields：Protein digestion and absorption

Gene Name：COL19A1

Protein Name：Collagen alpha-1(XIX) chain

Human Gene Id：1310

Human Swiss Prot No：Q14993

Mouse Swiss Prot No：Q0VF58

Immunogen：The antiserum was produced against synthesized peptide derived from human Collagen XIX alpha1. AA range:421-470

Specificity：COL19A1 Polyclonal Antibody detects endogenous levels of COL19A1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：COL19A1;Collagen alpha-1(XIX) chain;Collagen alpha-1(Y) chain

Observed Band(KD)：120kD

Background： This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008],

Function：domain:The numerous interruptions in the triple helix may make this molecule either elastic or flexible.,function:May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,subunit:Oligomer; disulfide-linked.,tissue specificity:Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.,

Subcellular Location：Secreted, extracellular space, extracellular matrix .

Expression：Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.