Target：Integrin α1
Fields：PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Human papillomavirus infection;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy
Gene Name：ITGA1
Protein Name：Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)
Human Gene Id：3672
Human Swiss Prot No：P56199
Mouse Gene Id：109700
Mouse Swiss Prot No：Q3V3R4
Immunogen：Synthetic peptide from human protein at AA range: 920-980
Specificity：The antibody detects endogenous Integrin α1
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Integrin alpha-1 (CD49 antigen-like family member A;Laminin and collagen receptor;VLA-1;CD antigen CD49a)
Background：integrin subunit alpha 1(ITGA1) Homo sapiens This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008],
Function：domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.,
Subcellular Location：Membrane; Single-pass type I membrane protein.
Expression： Brain,Liver,Plasma,
