Target：Fe65L

Gene Name：APBB2

Protein Name：Amyloid beta A4 precursor protein-binding family B member 2

Human Gene Id：323

Human Swiss Prot No：Q92870

Mouse Gene Id：11787

Mouse Swiss Prot No：Q9DBR4

Immunogen：The antiserum was produced against synthesized peptide derived from human APBB2. AA range:471-520

Specificity：Fe65L Polyclonal Antibody detects endogenous levels of Fe65L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：APBB2;FE65L;FE65L1;Amyloid beta A4 precursor protein-binding family B member 2;Protein Fe65-like 1

Observed Band(KD)：83kD

Background：amyloid beta precursor protein binding family B member 2(APBB2) Homo sapiens The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Function：function:May modulate the internalization of beta-amyloid precursor protein.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subunit:Binds to the intracellular domain of the beta-amyloid precursor protein.,

Subcellular Location：Endoplasmic reticulum . Golgi apparatus . Early endosome .

Expression：Widely expressed.