Target：Nov

Gene Name：NOV

Protein Name：Protein NOV homolog

Human Gene Id：4856

Human Swiss Prot No：P48745

Mouse Gene Id：18133

Mouse Swiss Prot No：Q64299

Rat Gene Id：81526

Rat Swiss Prot No：Q9QZQ5

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human NOV. AA range:221-270

Specificity：Nov Polyclonal Antibody detects endogenous levels of Nov protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NOV;CCN3;IGFBP9;NOVH;Protein NOV homolog;NovH;CCN family member 3;Insulin-like growth factor-binding protein 9;IBP-9;IGF-binding protein 9;IGFBP-9;Nephroblastoma-overexpressed gene protein homolog

Observed Band(KD)：39kD

Background： The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009],

Function：function:Immediate-early protein likely to play a role in cell growth regulation.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Interacts with FBLN1.,tissue specificity:Increased expression in Wilms tumor of the stromal type.,

Subcellular Location：Secreted. Cytoplasm . Cell junction, gap junction . Localizes at the gap junction in presence of GJA1. .

Expression：Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.