Target：NKX22

Fields：Maturity onset diabetes of the young

Gene Name：NKX2-2 NKX2.2 NKX2B

Protein Name：Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B)

Human Gene Id：4821

Human Swiss Prot No：O95096

Mouse Swiss Prot No：P42586

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：NKX22 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：30kD

Background： The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008],

Function：domain:The homeodomain is essential for interaction with OLIG2.,function:May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance.,similarity:Belongs to the NK-2 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with OLIG2.,

Subcellular Location：Nucleus .

Expression： Brain,