Target：NCX1

Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Apelin signaling pathway;Olfactory transduction;Endocrine and other factor-regulated calcium reabsorption;Protein digestion and absorption;Mineral absorption;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy

Gene Name：SLC8A1

Protein Name：Sodium/calcium exchanger 1

Human Gene Id：6546

Human Swiss Prot No：P32418

Mouse Gene Id：20541

Mouse Swiss Prot No：P70414

Rat Gene Id：29715

Rat Swiss Prot No：Q01728

Immunogen：Synthesized peptide derived from NCX1 . at AA range: 270-350

Specificity：NCX1 Polyclonal Antibody detects endogenous levels of NCX1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC8A1;CNC;NCX1;Sodium/calcium exchanger 1;Na(+)/Ca(2+)-exchange protein 1

Observed Band(KD)：108kD

Background： In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004],

Function：alternative products:Additional isoforms seem to exist,enzyme regulation:By ATP.,function:Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.,similarity:Contains 2 Calx-beta domains.,tissue specificity:Cardiac sarcolemma.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165).