Target：NARG1

Gene Name：NAA15

Protein Name：N-alpha-acetyltransferase 15 NatA auxiliary subunit

Human Gene Id：80155

Human Swiss Prot No：Q9BXJ9

Mouse Swiss Prot No：Q80UM3

Immunogen：The antiserum was produced against synthesized peptide derived from human NARG1. AA range:221-270

Specificity：NARG1 Polyclonal Antibody detects endogenous levels of NARG1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NAA15;GA19;NARG1;NATH;TBDN100;N-alpha-acetyltransferase 15; NatA auxiliary subunit;Gastric cancer antigen Ga19;N-terminal acetyltransferase;NMDA receptor-regulated protein 1;Protein tubedown-1;Tbdn100

Observed Band(KD)：100kD

Background： This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq, Jul 2008],

Function：function:The ARD1A-NARG1 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with G22P1 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.,PTM:Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 8 TPR repeats.,subcellular location:Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.,subunit:Interacts with ARD1A, G22P1, NAT13 and XRCC5.,tissue specificity:Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon

Subcellular Location：Cytoplasm. Nucleus. Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.

Expression：Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.