Target：SCN2B

Gene Name：SCN2B

Protein Name：Sodium channel subunit beta-2

Human Gene Id：6327

Human Swiss Prot No：O60939

Mouse Gene Id：72821

Mouse Swiss Prot No：Q56A07

Rat Gene Id：25349

Rat Swiss Prot No：P54900

Immunogen：The antiserum was produced against synthesized peptide derived from human SCN2B. AA range:71-120

Specificity：Na+ CP type IIβ Polyclonal Antibody detects endogenous levels of Na+ CP type IIβ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SCN2B;Sodium channel subunit beta-2

Observed Band(KD)：24kD

Background： The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015],

Function：function:Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR.,tissue specificity:Brain specific.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression：Brain specific.