Target：MYPT3

Gene Name：PPP1R16A

Protein Name：Protein phosphatase 1 regulatory subunit 16A

Human Gene Id：84988

Human Swiss Prot No：Q96I34

Mouse Swiss Prot No：Q923M0

Immunogen：The antiserum was produced against synthesized peptide derived from human PPP1R16A. AA range:362-411

Specificity：MYPT3 Polyclonal Antibody detects endogenous levels of MYPT3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPP1R16A;MYPT3;Protein phosphatase 1 regulatory subunit 16A;Myosin phosphatase-targeting subunit 3

Observed Band(KD)：60kD

Background： Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016],

Function：function:Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.,sequence caution:Cloning artifact.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,

Subcellular Location：Cell membrane ; Lipid-anchor .

Expression： Lung,Placenta,Spleen,Uterus,