Target：MYOZ2
Gene Name：MYOZ2 C4orf5
Protein Name：myozenin 2
Human Gene Id：51778
Human Swiss Prot No：Q9NPC6
Mouse Gene Id：59006
Mouse Swiss Prot No：Q9JJW5
Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human MYOZ2. AA range:21-70
Specificity：The antibody detects endogenous MYOZ2 protein
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：MYOZ2 C4orf5
Observed Band(KD)：30kD
Background： The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011],
Function：function:Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.,similarity:Belongs to the myozenin family.,subcellular location:Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.,subunit:Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ATCN1, LDB3, MYOT and PPP3CA.,tissue specificity:Expressed specifically in heart and skeletal muscle.,
Subcellular Location：Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. .
Expression：Expressed specifically in heart and skeletal muscle.
