Target：MYH

Fields：Base excision repair

Gene Name：MUTYH

Protein Name：A/G-specific adenine DNA glycosylase

Human Gene Id：4595

Human Swiss Prot No：Q9UIF7

Mouse Gene Id：70603

Mouse Swiss Prot No：Q99P21

Rat Gene Id：170841

Rat Swiss Prot No：Q8R5G2

Immunogen：The antiserum was produced against synthesized peptide derived from human MUTYH. AA range:151-200

Specificity：MYH Polyclonal Antibody detects endogenous levels of MYH protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MUTYH;MYH;A/G-specific adenine DNA glycosylase;MutY homolog;hMYH

Observed Band(KD)：60kD

Background： This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,disease:Defects in MUTYH are a cause of autosomal recessive colorectal adenomatous polyposis [MIM:608456].,disease:Defects in MUTYH are a cause of gastric cancer [MIM:137215].,function:Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.,similarity:Belongs to the nth/mutY family.,similarity:Contains 1 nudix hydrolase domain.,

Subcellular Location：Nucleus . Mitochondrion .

Expression： Kidney,