Target：MYBPC1

Gene Name：MYBPC1

Protein Name：Myosin-binding protein C slow-type

Human Gene Id：4604

Human Swiss Prot No：Q00872

Rat Gene Id：362867

Rat Swiss Prot No：Q63518

Immunogen：The antiserum was produced against synthesized peptide derived from human MYBPC1. AA range:218-267

Specificity：MYBPC1 Polyclonal Antibody detects endogenous levels of MYBPC1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MYBPC1;MYBPCS;Myosin-binding protein C; slow-type;Slow MyBP-C;C-protein, skeletal muscle slow isoform

Observed Band(KD)：120kD

Background： This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

Function：function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.,similarity:Belongs to the immunoglobulin superfamily. MyBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,

Subcellular Location：cytosol,myofibril,myosin filament,

Expression： Brain,Fetal skeletal muscle,Hippocampus,Liver,Muscle pool- 2 tissue