Target:MX1
Fields:Viral life cycle - HIV-1;Hepatitis C;Measles;Influenza A;Human papillomavirus infection;Coronavirus disease - COVID-19
Gene Name:MX1
Protein Name:Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance prot
Human Gene Id:4599
Human Swiss Prot No:P20591
Mouse Swiss Prot No:P09922
Rat Swiss Prot No:P18588
Immunogen:Synthesized peptide derived from human protein . at AA range: 500-580
Specificity:MX1 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):72kD
Background: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Function:function:May regulate the calcium channel activity of TRPCs. Shows activity against influenza virus and VSV, a rhabdovirus.,induction:By interferons.,similarity:Belongs to the dynamin family.,similarity:Contains 1 GED domain.,subunit:Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.,
Subcellular Location:Cytoplasm . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, perinuclear region . Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845). .; [Isoform 2]: Cytoplasm . Nucleus . Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636). .
Expression: Primary B-Cells,Spleen,Uterus,