Target：MUC7

Fields：Salivary secretion

Gene Name：MUC7 MG2

Protein Name：Mucin-7 (MUC-7) (Apo-MG2) (Salivary mucin-7)

Human Gene Id：4589

Human Swiss Prot No：Q8TAX7

Immunogen：Synthesized peptide derived from human protein . at AA range: 40-120

Specificity：MUC7 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：41kD

Background：mucin 7, secreted(MUC7) Homo sapiens This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014],

Function：disease:MUC7 alleles are associated with susceptibility to asthma [MIM:600807]. The MUC7*5 allele is rarer in the atopic asthmatics than in the atopic non-asthmatics. Comparison of all atopic individuals with all nonatopic shows no difference, while comparison of all asthmatic individuals with all non-asthmatic shows that the asthmatic group has reduced MUC7*5 frequency. The significantly lower frequency of the MUC7*5 allele in individuals with atopic asthma was explained by the possible association between alleles and different interactions with bacteria, since the glycosylated domain is thought to be responsible, at least in part, for the bacterial binding that allows bacteria to be cleared from the epithelial surfaces.,function:May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeru

Subcellular Location：Secreted .

Expression：Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).