Target：mtTFA

Fields：Apelin signaling pathway;Huntington disease

Gene Name：TFAM

Protein Name：Transcription factor A mitochondrial

Human Gene Id：7019

Human Swiss Prot No：Q00059

Mouse Swiss Prot No：P40630

Immunogen：The antiserum was produced against synthesized peptide derived from human TFAM. AA range:131-180

Specificity：mtTFA Polyclonal Antibody detects endogenous levels of mtTFA protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TFAM;TCF6;TCF6L2;Transcription factor A; mitochondrial;mtTFA;Mitochondrial transcription factor 1;MtTF1;Transcription factor 6;TCF-6;Transcription factor 6-like 2

Observed Band(KD)：22kd

Background： This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Function：function:Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Interacts with TFB1M and TFB2M.,

Subcellular Location：Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .

Expression： Lymphocyte,Pooled,Uterus,