Target：MST3

Gene Name：STK24

Protein Name：Serine/threonine-protein kinase 24

Human Gene Id：8428

Human Swiss Prot No：Q9Y6E0

Mouse Gene Id：223255

Mouse Swiss Prot No：Q99KH8

Rat Gene Id：361092

Rat Swiss Prot No：B0LT89

Immunogen：The antiserum was produced against synthesized peptide derived from human STK24. AA range:319-368

Specificity：MST-3 Polyclonal Antibody detects endogenous levels of MST-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：STK24;MST3;STK3;Serine/threonine-protein kinase 24;Mammalian STE20-like protein kinase 3;MST-3;STE20-like kinase MST3

Observed Band(KD)：50kD

Background： This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Manganese. Only isoform A requires manganese.,function:Protein kinase that act on both serine and threonine residues.,PTM:Autophosphorylated. Isoform B is activated by phosphorylation by PKA.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.,

Subcellular Location：Cytoplasm. Nucleus. Membrane. The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.

Expression：Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.