Target：MN1

Gene Name：MN1

Protein Name：Probable tumor suppressor protein MN1

Human Gene Id：4330

Human Swiss Prot No：Q10571

Immunogen：The antiserum was produced against synthesized peptide derived from human MN1. AA range:821-870

Specificity：MN1 Polyclonal Antibody detects endogenous levels of MN1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MN1;Probable tumor suppressor protein MN1

Observed Band(KD)：135kD

Background： Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008],

Function：disease:A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL.,disease:Defects in MN1 may be a cause of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.,function:May play a role in tumor suppression.,tissue specificity:Ubiquitously expressed. Highest levels in skeletal muscle.,

Subcellular Location：Nucleus .

Expression：Widely expressed in fetal and adult tissues. Highest expression is observed in fetal brain and skeletal muscle, and adult skeletal muscle.