Target：MLK2

Fields：Huntington disease;Pathways of neurodegeneration - multiple diseases

Gene Name：MAP3K10

Protein Name：Mitogen-activated protein kinase kinase kinase 10

Human Gene Id：4294

Human Swiss Prot No：Q02779

Mouse Swiss Prot No：Q66L42

Immunogen：The antiserum was produced against synthesized peptide derived from human MAP3K10. AA range:391-440

Specificity：MLK2 Polyclonal Antibody detects endogenous levels of MLK2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MAP3K10;MLK2;MST;Mitogen-activated protein kinase kinase kinase 10;Mixed lineage kinase 2;Protein kinase MST

Molecular Weight(Da)：104kD

Background： The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in brain and skeletal muscle.,

Subcellular Location：intracellular,cytoplasm,

Expression：Expressed in brain and skeletal muscle.