Target：MLK1
Gene Name：MAP3K9
Protein Name：Mitogen-activated protein kinase kinase kinase 9
Human Gene Id：4293
Human Swiss Prot No：P80192
Mouse Gene Id：338372
Mouse Swiss Prot No：Q3U1V8
Immunogen：The antiserum was produced against synthesized peptide derived from human MAP3K9. AA range:561-610
Specificity：MLK1 Polyclonal Antibody detects endogenous levels of MLK1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：MAP3K9;MLK1;PRKE1;Mitogen-activated protein kinase kinase kinase 9;Mixed lineage kinase 1
Molecular Weight(Da)：122kD
Background：MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include retroperitoneal neuroblastoma. Among its related pathways are MAP Kinase Signaling andTGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.,
Subcellular Location：intracellular,integral component of membrane,
Expression：Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
