Target：MKP-5

Fields：MAPK signaling pathway

Gene Name：DUSP10

Protein Name：Dual specificity protein phosphatase 10

Human Gene Id：11221

Human Swiss Prot No：Q9Y6W6

Mouse Gene Id：63953

Mouse Swiss Prot No：Q9ESS0

Immunogen：Synthesized peptide derived from MKP-5 . at AA range: 330-410

Specificity：MKP-5 Polyclonal Antibody detects endogenous levels of MKP-5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DUSP10;MKP5;Dual specificity protein phosphatase 10;Mitogen-activated protein kinase phosphatase 5;MAP kinase phosphatase 5;MKP-5

Observed Band(KD)：52kD

Background：dual specificity phosphatase 10(DUSP10) Homo sapiens Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],

Function：catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

Subcellular Location：Cytoplasm. Nucleus.

Expression：Expressed in keratinocytes (at protein level) (PubMed:29043977). Detected in brain (PubMed:16806267).