Target：MK

Gene Name：MDK

Protein Name：Midkine

Human Gene Id：4192

Human Swiss Prot No：P21741

Mouse Swiss Prot No：P12025

Rat Gene Id：81517

Rat Swiss Prot No：Q9R1S9

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human MDK. AA range:94-143

Specificity：MK Polyclonal Antibody detects endogenous levels of MK protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MDK;MK1;NEGF2;Midkine;MK;Amphiregulin-associated protein;ARAP;Midgestation and kidney protein;Neurite outgrowth-promoting factor 2;Neurite outgrowth-promoting protein

Observed Band(KD)：18kD

Background： This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012],

Function：function:Has heparin binding activity, and growth promoting activity. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.,induction:By heparin and retinoic acid.,similarity:Belongs to the pleiotrophin family.,subunit:Homodimer.,

Subcellular Location：Secreted.

Expression：Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.