Target：MGRN1

Fields：Ubiquitin mediated proteolysis;Hedgehog signaling pathway

Gene Name：MGRN1 KIAA0544 RNF156

Protein Name：E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin RING finger protein 1) (RING finger protein 156)

Human Gene Id：23295

Human Swiss Prot No：O60291

Mouse Swiss Prot No：Q9D074

Rat Swiss Prot No：Q5XIQ4

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：MGRN1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：60kD

Background： Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004],

Function：domain:The RING finger is required for ubiquitin ligase activity.,function:Probable E3 ubiquitin-protein ligase.,pathway:Protein modification; protein ubiquitination.,PTM:Autoubiquitinated in vitro.,similarity:Contains 1 RING-type zinc finger.,

Subcellular Location：Early endosome . The endosomal localization is dependent on the interaction with TSG101.; [Isoform 1]: Cytoplasm, cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 2]: Cytoplasm, cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.; [Isoform 3]: Cytoplasm, cytosol. Cell membrane.; [Isoform 4]: Cytoplasm, cytosol. Cell membrane.

Expression： Brain,Leukocyte,