Target：mGluR-8
Fields：Phospholipase D signaling pathway;Neuroactive ligand-receptor interaction;Glutamatergic synapse
Gene Name：GRM8
Protein Name：Metabotropic glutamate receptor 8
Human Gene Id：2918
Human Swiss Prot No：O00222
Mouse Swiss Prot No：P47743
Rat Gene Id：60590
Rat Swiss Prot No：P70579
Immunogen：The antiserum was produced against synthesized peptide derived from human mGluR8. AA range:841-890
Specificity：mGluR-8 Polyclonal Antibody detects endogenous levels of mGluR-8 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GRM8;GPRC1H;MGLUR8;Metabotropic glutamate receptor 8;mGluR8
Observed Band(KD)：100kD
Background：glutamate metabotropic receptor 8(GRM8) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been d
Function：function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with PICK1.,
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Expression： Brain,Colon,Fetal brain,
