Target：mGluR1

Fields：Calcium signaling pathway;FoxO signaling pathway;Phospholipase D signaling pathway;Neuroactive ligand-receptor interaction;Gap junction;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Long-term depression;Taste transduction;Estrogen signaling pathway;Spinocerebellar ataxia;Pathways of neurodegeneration - multiple diseases

Gene Name：GRM1

Protein Name：Metabotropic glutamate receptor 1

Human Gene Id：2911

Human Swiss Prot No：Q13255

Mouse Gene Id：14816

Mouse Swiss Prot No：P97772

Rat Gene Id：24414

Rat Swiss Prot No：P23385

Immunogen：The antiserum was produced against synthesized peptide derived from human GRM1. AA range:251-300

Specificity：mGluR1 Polyclonal Antibody detects endogenous levels of mGluR1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GRM1;GPRC1A;MGLUR1;Metabotropic glutamate receptor 1;mGluR1

Molecular Weight(Da)：132kD

Background：glutamate metabotropic receptor 1(GRM1) Homo sapiens This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],

Function：function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in brain.