Target：ACTR-IC

Fields：Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling pathways regulating pluripotency of stem cells

Gene Name：ACVR1C

Protein Name：Activin receptor type-1C

Human Gene Id：130399

Human Swiss Prot No：Q8NER5

Mouse Gene Id：269275

Mouse Swiss Prot No：Q8K348

Rat Gene Id：245921

Rat Swiss Prot No：P70539

Immunogen：The antiserum was produced against synthesized peptide derived from human ACTR-1C. AA range:201-250

Specificity：ACTR-IC Polyclonal Antibody detects endogenous levels of ACTR-IC protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ACVR1C;ALK7;Activin receptor type-1C;Activin receptor type IC;ACTR-IC;Activin receptor-like kinase 7;ALK-7

Molecular Weight(Da)：55kD

Background： ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008],

Function：catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds the type 2 receptor protein ACVR2A.,tissue specificity:Present in pancreas, heart, colon, small intestine, ovary and

Subcellular Location：Membrane ; Single-pass type I membrane protein .

Expression：Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.