Target:MEL-1B-R
Fields:Neuroactive ligand-receptor interaction;Circadian entrainment
Gene Name:MTNR1B
Protein Name:Melatonin receptor type 1B
Human Gene Id:4544
Human Swiss Prot No:P49286
Mouse Swiss Prot No:Q8CIQ6
Immunogen:The antiserum was produced against synthesized peptide derived from human MTR1B. AA range:301-350
Specificity:MEL-1B-R Polyclonal Antibody detects endogenous levels of MEL-1B-R protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:MTNR1B;Melatonin receptor type 1B;Mel-1B-R;Mel1b receptor
Observed Band(KD):40kD
Background: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008],
Function:function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retina and less in brain and hippocampus.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Expressed in retina and less in brain and hippocampus.