Target:OCT3
Fields:Choline metabolism in cancer
Gene Name:SLC22A3
Protein Name:Solute carrier family 22 member 3
Human Gene Id:6581
Human Swiss Prot No:O75751
Mouse Swiss Prot No:Q9WTW5
Immunogen:The antiserum was produced against synthesized peptide derived from human SLC22A3. AA range:275-324
Specificity:OCT3 Polyclonal Antibody detects endogenous levels of 40819 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:SLC22A3;EMTH;OCT3;Solute carrier family 22 member 3;Extraneuronal monoamine transporter;EMT;Organic cation transporter 3
Observed Band(KD):61kD
Background: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008],
Function:function:Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.,similarity:Belongs to the major facilitator superfamily. Organic cation transporter family.,tissue specificity:Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.,
Subcellular Location:Membrane; Multi-pass membrane protein.
Expression:Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.