Target：OAS2

Fields：NOD-like receptor signaling pathway;Hepatitis C;Measles;Influenza A;Herpes simplex virus 1 infection;Epstein-Barr virus infection;Coronavirus disease - COVID-19

Gene Name：OAS2

Protein Name：2'-5'-oligoadenylate synthase 2

Human Gene Id：4939

Human Swiss Prot No：P29728

Mouse Gene Id：246728

Mouse Swiss Prot No：E9Q9A9

Rat Gene Id：363938

Rat Swiss Prot No：Q5MYU0

Immunogen：The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110

Specificity：OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：OAS2;2'-5'-oligoadenylate synthase 2;(2-5')oligo(A) synthase 2;2-5A synthase 2;p69 OAS / p71 OAS;p69OAS / p71OAS

Observed Band(KD)：82kD

Background：2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer.,

Subcellular Location：Cytoplasm . Cytoplasm, perinuclear region .

Expression： Blood,Colon,Testis,Uterus,