Target：PLA1A
Fields：Glycerophospholipid metabolism;Ras signaling pathway
Gene Name：PLA1A
Protein Name：Phospholipase A1 member A
Human Gene Id：51365
Human Swiss Prot No：Q53H76
Mouse Swiss Prot No：Q8VI78
Immunogen：The antiserum was produced against synthesized peptide derived from human PLA1A. AA range:381-430
Specificity：PLA1A Polyclonal Antibody detects endogenous levels of PLA1A protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PLA1A;NMD;PSPLA1;Phospholipase A1 member A;Phosphatidylserine-specific phospholipase A1;PS-PLA1
Observed Band(KD)：45-50kD
Background： The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011],
Function：function:Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,tissue specificity:Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.,
Subcellular Location：Secreted .
Expression：Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
