Target:NUD12
Fields:Nicotinate and nicotinamide metabolism;Metabolic pathways;Peroxisome
Gene Name:NUDT12
Protein Name:Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12)
Human Gene Id:83594
Human Swiss Prot No:Q9BQG2
Mouse Swiss Prot No:Q9DCN1
Immunogen:Synthesized peptide derived from human protein . at AA range: 80-160
Specificity:NUD12 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):50kD
Background: Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008],
Function:catalytic activity:NAD(+) + H(2)O = AMP + NMN.,cofactor:Magnesium or manganese.,function:Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.,similarity:Belongs to the Nudix hydrolase family. NudC subfamily.,similarity:Contains 3 ANK repeats.,
Subcellular Location:Cytoplasm . Peroxisome . Cytoplasmic granule . Localizes to cytoplasmic granules in the presence of BLMH. .
Expression: Amygdala,Eye,Ovary,