Target：NSUN5

Gene Name：NSUN5 WBSCR20 WBSCR20A

Protein Name：Putative methyltransferase NSUN5 (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)

Human Gene Id：55695

Human Swiss Prot No：Q96P11

Mouse Swiss Prot No：Q8K4F6

Immunogen：Synthesized peptide derived from human protein . at AA range: 320-400

Specificity：NSUN5 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：47kD

Background： This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],

Function：function:May have S-adenosyl-L-methionine-dependent methyl-transferase activity .,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the methyltransferase superfamily. RsmB/NOP family.,tissue specificity:Ubiquitous. Detected in placenta, heart and skeletal muscle.,

Subcellular Location：Nucleus, nucleolus .

Expression：Ubiquitous (PubMed:11978965, PubMed:12073013). Detected in placenta, heart and skeletal muscle (PubMed:11978965, PubMed:12073013).