Target：Nrl
Gene Name：NRL
Protein Name：Neural retina-specific leucine zipper protein
Human Gene Id：4901
Human Swiss Prot No：P54845
Mouse Gene Id：18185
Mouse Swiss Prot No：P54846
Immunogen：The antiserum was produced against synthesized peptide derived from human NRL. AA range:19-68
Specificity：Nrl Polyclonal Antibody detects endogenous levels of Nrl protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：NRL;D14S46E;Neural retina-specific leucine zipper protein;NRL
Observed Band(KD)：25kD
Background： This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008],
Function：disease:Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27) [MIM:162080]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant.,function:Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Interacts with FIZ1. This interaction represses transactivation.,tissue specificity:Neural retina.,
Subcellular Location：Cytoplasm . Nucleus .
Expression：Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108).
