Target:Nrf3
Gene Name:NFE2L3
Protein Name:Nuclear factor erythroid 2-related factor 3
Human Gene Id:9603
Human Swiss Prot No:Q9Y4A8
Mouse Swiss Prot No:Q9WTM4
Immunogen:The antiserum was produced against synthesized peptide derived from human NFE2L3. AA range:491-540
Specificity:Nrf3 Polyclonal Antibody detects endogenous levels of Nrf3 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:NFE2L3;NRF3;Nuclear factor erythroid 2-related factor 3;NF-E2-related factor 3;NFE2-related factor 3;Nuclear factor; erythroid derived 2, like 3
Observed Band(KD):75kD
Background: This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009],
Function:function:Activates erythroid-specific, globin gene expression.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).,tissue specificity:Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.,
Subcellular Location:Nucleus .
Expression:Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.