Target：NRBF-2

Fields：Autophagy - animal;Alzheimer disease;Amyotrophic lateral sclerosis;Huntington disease;Spinocerebellar ataxia;Pathways of neurodegeneration - multiple diseases

Gene Name：NRBF2

Protein Name：Nuclear receptor-binding factor 2

Human Gene Id：29982

Human Swiss Prot No：Q96F24

Mouse Gene Id：641340

Mouse Swiss Prot No：Q8VCQ3

Rat Gene Id：58839

Rat Swiss Prot No：Q9QYK3

Immunogen：The antiserum was produced against synthesized peptide derived from human NRBF2. AA range:140-189

Specificity：NRBF-2 Polyclonal Antibody detects endogenous levels of NRBF-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NRBF2;COPR;Nuclear receptor-binding factor 2;NRBF-2;Comodulator of PPAR and RXR

Observed Band(KD)：36kD

Background：function:May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).,subunit:Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand.,tissue specificity:Detected in keratinocytes, liver and placenta.,

Function：function:May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).,subunit:Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand.,tissue specificity:Detected in keratinocytes, liver and placenta.,

Subcellular Location：Nucleus . Cytoplasm . Cytoplasmic vesicle . Cytoplasmic vesicle, autophagosome .

Expression：Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852).