Target：OSBL6

Gene Name：OSBPL6 ORP6

Protein Name：Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)

Human Gene Id：114880

Human Swiss Prot No：Q9BZF3

Mouse Swiss Prot No：Q8BXR9

Immunogen：Synthesized peptide derived from human protein . at AA range: 260-340

Specificity：OSBL6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：102kD

Background： This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Function：PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,tissue specificity:Widely expressed.,

Subcellular Location：Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus envelope . Cell membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. .

Expression：Expressed in brain and striated muscle (at protein level) (PubMed:14593528). Widely expressed (PubMed:11735225). Expressed in skeletal muscle (PubMed:14593528).