Target:Orexin R-1
Fields:Neuroactive ligand-receptor interaction
Gene Name:HCRTR1
Protein Name:Orexin receptor type 1
Human Gene Id:3061
Human Swiss Prot No:O43613
Mouse Gene Id:230777
Mouse Swiss Prot No:P58307
Rat Gene Id:25593
Rat Swiss Prot No:P56718
Immunogen:The antiserum was produced against synthesized peptide derived from human HCRTR1. AA range:231-280
Specificity:Orexin R-1 Polyclonal Antibody detects endogenous levels of Orexin R-1 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:HCRTR1;Orexin receptor type 1;Ox-1-R;Ox1-R;Ox1R;Hypocretin receptor type 1
Observed Band(KD):50kD
Background: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009],
Function:function:Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Subcellular Location:Cell membrane ; Multi-pass membrane protein .
Expression: Brain,