Target：P2Y4

Fields：Neuroactive ligand-receptor interaction;Taste transduction

Gene Name：P2RY4

Protein Name：P2Y purinoceptor 4

Human Gene Id：5030

Human Swiss Prot No：P51582

Mouse Gene Id：57385

Mouse Swiss Prot No：Q9JJS7

Rat Gene Id：63843

Rat Swiss Prot No：O35811

Immunogen：The antiserum was produced against synthesized peptide derived from human P2RY4. AA range:159-208

Specificity：P2Y4 Polyclonal Antibody detects endogenous levels of P2Y4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：P2RY4;NRU;P2Y purinoceptor 4;P2Y4;P2P;Uridine nucleotide receptor;UNR

Observed Band(KD)：41kD

Background： The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008],

Function：function:Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.,PTM:Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Pancreas.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Pancreas.