Target：P2X3

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction;Taste transduction

Gene Name：P2RX3

Protein Name：P2X purinoceptor 3

Human Gene Id：5024

Human Swiss Prot No：P56373

Mouse Gene Id：228139

Mouse Swiss Prot No：Q3UR32

Rat Gene Id：81739

Rat Swiss Prot No：P49654

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human P2RX3. AA range:81-130

Specificity：P2X3 Polyclonal Antibody detects endogenous levels of P2X3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：P2RX3;P2X purinoceptor 3;P2X3;ATP receptor;Purinergic receptor

Observed Band(KD)：44kD

Background： The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008],

Function：function:Receptor for ATP that acts as a ligand gated ion channel.,online information:P2X receptor entry,similarity:Belongs to the P2X receptor family.,subunit:Homo- or heteropolymers.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression： Heart,