Target：P2RY6

Fields：Neuroactive ligand-receptor interaction

Gene Name：P2RY6 PP2891

Protein Name：P2Y purinoceptor 6 (P2Y6)

Human Gene Id：5031

Human Swiss Prot No：Q15077

Mouse Swiss Prot No：Q9ERK9

Rat Swiss Prot No：Q63371

Immunogen：Synthesized peptide derived from human protein . at AA range: 180-260

Specificity：P2RY6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：36kD

Background： The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013],

Function：function:Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Brain,Placenta,