Target：P2RX1

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction;Platelet activation

Gene Name：P2RX1 P2X1

Protein Name：P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)

Human Gene Id：5023

Human Swiss Prot No：P51575

Mouse Swiss Prot No：P51576

Rat Swiss Prot No：P47824

Immunogen：Synthesized peptide derived from human protein . at AA range: 150-230

Specificity：P2RX1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：43kD

Background： The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013],

Function：disease:Defects in P2RX1 are a cause of bleeding disorder [MIM:600845].,function:Ligand gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.,online information:P2RX1 entry,online information:P2X receptor entry,similarity:Belongs to the P2X receptor family.,subunit:Homo- or heteropolymers.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression： Blood,Lung,Placenta,Platelet,Urinary bladder,Urinary bladder smooth muscle,